SUMOylation of Vps34 by SUMO1 promotes phenotypic switching of vascular smooth muscle cells by activating autophagy in pulmonary arterial hypertension
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چکیده
منابع مشابه
Upregulation of Autophagy by Angiotensin II Triggers Phenotypic Switching of Aortic Vascular Smooth Muscle Cells
Methods and Results: In this study, we found AngII infusion promotes a increased form of autophagy characterized by increased expression of Beclin1 and LC3-II in the cultured human aortic vascular smooth muscle cells. The growth of autophagy stimulated by AngII could enhance implication of synthetic proteins in VSMCs, while inhibition of autophagy with spautin-1or 3-MA can encourage the stabili...
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BACKGROUND Vascular hyperproliferative disorders are characterized by excessive smooth muscle cell (SMC) proliferation leading to vessel remodeling and occlusion. In pulmonary arterial hypertension (PAH), SMC phenotype switching from a terminally differentiated contractile to synthetic state is gaining traction as our understanding of the disease progression improves. While maintenance of SMC c...
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Objective(s): To investigate the role of autophagy in advanced glycation end products (AGEs)-induced proliferation and migration in rat vascular smooth muscle cells (VSMCs).Materials and Methods: After culture, VSMCs were treated with 0, 1, 10, and 100 μg/ml concentrations of AGEs. Autophagy specific protein light chain 3 (LC3)-I/II was determined by western blotting, autophagosomes were observ...
متن کاملpulmonary vascular capacitance as a predictor of vasoreactivity in idiopathic pulmonary arterial hypertension tested by adenosine
conclusions cp could be considered as an index for the prediction of vasoreactivity in patients with ipah. prediction of long-term response to calcium channel blockers in patients with ipah and a positive vasoreactive test by this index should be addressed in further studies. patients and methods fourteen patients with ipah and a vasoreactive adenosine vasoreactivity testing according to the es...
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ژورنال
عنوان ژورنال: Pulmonary Pharmacology & Therapeutics
سال: 2019
ISSN: 1094-5539
DOI: 10.1016/j.pupt.2019.01.007